This revealed that tumor cells in MBMs not only exhibited significantly upregulated tumorigenesis and maintenance genes (e.g., MET and TBX2), but also expressed neural differentiation markers (e.g., NRG3, NELL1, NCAM1, ADNP) and cell adhesion molecules (e.g., CDH1, PRKCA) (Fig 3C, S3 Table). Here, NRG3 is linked to neoplasm.