AXL and melanoma: Consequently, MITFhigh melanoma cells exhibit a proliferative yet non-invasive phenotype, whereas MITFlow populations demonstrate enhanced invasiveness and metastatic potential [18,20–22] This phenotypic plasticity is further mediated by AXL-driven molecular reprogramming, which facilitates the transition from an epithelial to an aggressive mesenchymal state in melanoma [23].