Additionally, bacteria producing lipopolysaccharides in cancer patients may activate the IL-6/Janus Kinase 1 (JAK1)/Signal Transducer and Activator of Transcription 3 (STAT3) signaling pathway [17], indicating that the imbalance of gastric microbiota has potential roles in the formation of CAG, PLGC, and gastric cancer, and the IL-6/JAK1/STAT3 signaling pathway may be involved. This evidence concerns the gene STAT3 and cancer.