CLU and Alzheimer disease: Plasma/platelet clusterin ratio has been observed to be associated with greater severity in NPI domains of disinhibition, aberrant motor behavior, and irritability in patients with AD.167 Another group found positive associations between plasma ceramides and delusions in the mild AD stage.171 Other NPS, such as hallucinations, elation, anxiety, and appetite changes, are less frequent and did not have positive findings in other studies.