Further, a tau-PET study demonstrated effect modification by amyloid status for MBI-associated tau tracer uptake in early-stage AD Braak regions; the association was observed only in Aβ-positive participants.143 These findings extend those from the BioFINDER-2 preclinical-AD study,136 and highlight a need to investigate the relationship between MBI and plasma tau in the context of Aβ. This evidence concerns the gene MAPT and Alzheimer disease.