TP53 and neoplasm: The TP53 gene codes for a transcription factorand a well-known tumor suppressor that regulates multitude intracellularpathways involved in DNA damage repair, cell cycle arrest, apoptosis,and senescence., Mutations in TP53 leading to its inactivation are involved in tumorigenesis and arefound to be prevalent in more than 50% of human primary tumors. Majority of TP53 mutationsare missense mutations (around 80%) occurring due to guanine (G) toadenine (A) transitions, followed by cytosine (C) to thymine (T) transitions.These are clustered in the central DNA-binding region consisting ofexons 3–5.