Recently,using CRISPR screens, a compelling lethal interaction between thehelicase-encoding WRN gene and microsatellite instabilitywas identified., In immuno-oncology, the molecularmechanism of tumor immune evasion was explored, which included multiplefactors like Ras signaling, antigen presentation, interferon, autophagy,and epigenetic remodeling.−,  In another study, a CRISPR-basedscreening approach showed that depletion of neurofibromin, merlin,and the mediator complex component MED12 conferred resistance to vemurafenib,a B-Raf enzyme inhibitor, in B-RAF mutant melanoma cells. Here, BRAF is linked to neoplasm.