Mechanistically, hsa_circ_0044235 [182] ameliorates rheumatoid arthritis (RA) progression through the miR‐135b‐5p/SIRT1 axis, demonstrating anti‐inflammatory and antipyroptotic effects in both collagen‐induced arthritis mouse models and fibroblast‐like synoviocytes (FLSs) [182]. The gene discussed is SIRT1; the disease is rheumatoid arthritis.