This effect appears to be mediated, at least in part, by the recruitment and activation of immunosuppressive cells such as M2-like tumour associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and ST2+ regulatory T cells (Tregs), all of which contribute to immune evasion and subsequent tumour progression [80,96]. This evidence concerns the gene IL1RL1 and neoplasm.