A key difference following dual blockade is the significant reduction in populations of immunosuppressive cells, including myeloid-derived suppressor cells (MDSCs) and regulatory T cells, both systemically (MDSCs: ST2–/– + antiPD1 vs. WT= 53,0 vs. 73,6%; Tregs: ST2–/– + antiPD1 vs. WT= 1,74 vs. 3,54%) and within tumours (MDSCs: ST2–/– + antiPD1 vs. WT= 60,0 vs. 82,5%; Tregs: ST2–/– + antiPD1 vs. WT= 0,83 vs. 3,07%) [108]. Here, IL1RL1 is linked to neoplasm.