Additionally, miR-455-5p promotes triple-negative breast cancer growth and immune evasion by targeting SOCS3, a negative regulator of cytokine signalling [125] suggesting that microRNA-mediated modulation of ­cytokine pathways could influence responses to IL-33/ST2 and PD-1/PD-L1 co-inhibition. The gene discussed is CD274; the disease is triple-negative breast carcinoma.