However, in pathological states, Pra can acutely rise above Pcrit. Common examples include acute volume overload in the setting of right ventricular dysfunction and/or acute pulmonary hypertension (e.g., hyperinflation, asthma), increased intrathoracic pressure (e.g., tension pneumothorax), or increased pericardial pressure (e.g., cardiac tamponade) [24–27]. This evidence concerns the gene S100A6 and asthma.