In previous studies, through GSVA enrichment analysis, we obtained 17 core genes (TOP2A, KIF20A, CCNB2, AURKA, KIF11, CDK1, BUB1B, CCNA2, BUB1, CDC20, CDCA8, TPX2, KIF2C, POLA2, POLE2, POLA1 and POLE) that affect the survival prognosis of patients, and since TOP2A order is the highest we found that TOP2A is associated with the clinical features of brain gliomas through a series of bioinformatics databases and statistical analyses. The gene discussed is POLE2; the disease is brain glioma.