Some studies have indicated phenotypic overlap between Noonan syndrome, neurofibromatosis type 1, and schwannomatosis, including germline LZTR1 variants associated with only café-au-lait macules [66], as well as case reports of LZTR1-related Noonan syndrome and vestibular schwannoma[67], or nerve tumours that are likely to be schwannomas [68]. Here, LZTR1 is linked to Cafe-au-lait spot.