LZTR1 and schwannomatosis: In addition, in gnomAD v4 (gnomAD) data, 1 in 323 people have a loss-of-function variant in LZTR1. Since LZTR1-SWN only occurs in approximately 1 in 527,000 people [2], this means that under 0.1% of people with a heterozygous loss-of-function variant in LZTR1 actually develop schwannomatosis.