Although painful schwannomas have generally been shown to express higher levels of inflammatory cytokines, such as interleukin-6, interleukin-8 and vascular endothelial growth factor (VEGF) than non-painful schwannomas, the secretomes of schwannomas associated with a pathogenic SMARCB1 variant differ from those with a pathogenic LZTR1 variant [5, 6]. The gene discussed is IL6; the disease is schwannoma.