KIT and chronic myelogenous leukemia, BCR-ABL1 positive: Notable examples include minoxidil, originally an antihypertensive agent, now widely repurposed for male-pattern hair loss [18], and imatinib, first approved for chronic myeloid leukemia (CML) and later found effective against gastrointestinal stromal tumors (GISTs) through inhibition of the KIT (CD117) tyrosine kinase [19].