ii) Risk management of OHSS: Although the overall incidence of OHSS in the GnRH-A protocol is lower than that in the GnRH-a protocol, more stringent risk control measures are implemented for patients with ovarian hyperresponse (e.g. patients with polycystic ovary syndrome, young patients, or those with a high AFC). Here, GNRH1 is linked to ovarian hyperstimulation syndrome.