We have developedpalmitate-containing ionizable LNPs functionalized with (i) octreotide(Oct), targeting somatostatin receptor type 2 (SSTR2)-expressing tumorcells, and (ii) penetratin (RK16), enhancing intracellular uptake.This dually decorated LNP codelivered two siRNAs targeting tumor-promotinggenes (heat shock protein 27 (Hsp27) and human epidermal growth factorreceptor 2 (HER2)) into HER2+ breast cancer cells, demonstratingstrong potential for combinatorial therapies. This evidence concerns the gene ERBB2 and breast cancer.