Infected cells upregulated microRNAs 25 and 93 and reduced MARCH1 mRNA following either HIV-1, HIV-2, or SIVmac239 infection, thus validating this cell model to study the interplay between the levels of microRNAs 25 and 93 and MARCH1 mRNA expression (Fig. 3). The gene discussed is MARCHF1; the disease is infection.