CT findings raised the suspicion of vaso-occlusive disease, and, in particular, moyamoya disease; to exclude secondary causes of moyamoya disease, the following parameters were also evaluated: autoimmune panel (ANA, ENA, anti-dsDNA, and ANCA), thyroid function and antibodies (TSH, FT3, FT4, and anti-TPO), infectious screening (HBV, HCV, HIV, and syphilis), and thrombophilia panel; all of these parameters showed normal values. The gene discussed is TPO; the disease is Moyamoya disease.