CEACAM5 and neoplasm: However, in MKN45 and HPAFII in vivo xenograft models in humanized NSG mice, the CEA-4-1BBL antibody fusion protein constructed with the CEACAM5 antibody T84.66-LCHA targeting a membrane-proximal CEACAM5 epitope showed the best tumor control overall in combination with CEA-TCB.