In scientific communications, immature Breg cells with IL-10 expression are decreased in some autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis, or multiple sclerosis, among others, as reported in several studies; in conditions where immune system dysregulation and disruption of the correct state of homeostasis are actually key; and in those where potential specific environmental signals may also further determine the polarization, percentage, and function of B-lineage regulatory cells [20,21,22]. This evidence concerns the gene IL10 and multiple sclerosis.