Genetic analysis revealed multiple pathogenic variants of 14 genes, including SAMD9L, Ly96, REL, IRAK1, RBPJ, IL6ST, TNFAIP3, ITGA2B, ABCC2, AIRE, IL6R, JAZF1, IKZF3, and AFF3, in the group of SSc patients (Table 4). The gene discussed is TNFAIP3; the disease is systemic sclerosis.