The association was also found with skin lesions, Raynaud’s phenomenon, ILD, and esophagitis (χ2 = 16.2–40.9, p < 0.0001), though further studies with larger cohorts are required to determine whether JAZF1 contributes synergistically to pro-fibrotic and vascular mechanisms in SSc. The gene discussed is JAZF1; the disease is interstitial lung disease.