Indeed, in our research, an increased level of Anti-Scl-70 was detected in one male patient, with a rapidly progressive course of SSc-ILD, pulmonary arterial hypertension, Raynaud’s syndrome, skin injury, esophagitis, arthritis, and Sjogren’s syndrome with anti-SS-A/60 and SS-A/52 antibodies. Here, TRIM21 is linked to arthritic joint disease.