Among the genes whose expression changed upon the treatment with anti-cN1A-positive serum when compared with both anti-cN1A-negative IBM serum and healthy serum treatments, 538 were upregulated, 498 were downregulated and, interestingly, 89 were changed in the opposite directions, for example upregulated when compared with healthy serum treatment and downregulated when compared with anti-cN1A negative serum or visa versa (Figure 4). Here, NT5C1A is linked to inclusion body myositis.