PTGS2 and aortic aneurysm: Development of aortic aneurysms and atherosclerosis is facilitated by disturbed oscillatory blood flows, triggering ECs to express inflammatory genes and ROS generation, which in turn stimulates the expression and activity of proinflammatory markers, including the transcription factor nuclear factor (NF)κ-B and cyclooxygenase (COX)-2 [13,14].