Mucopolysaccharidosis Type I (MPS I) is an autosomal recessive lysosomal storage disorder (LSD) caused by deficiency of alpha-iduronidase (IDUA), which is essential for the degradation of glycosaminoglycans (GAGs) such as dermatan sulfate (DS) and heparan sulfate (HS) [1,2,3,4,5,6]. This evidence concerns the gene MAP3K14 and Scheie syndrome.