In this context, this review is focused on the lncRNA Colitis Associated IRF1 antisense Regulator of Intestinal Homeostasis (CARINH), a lncRNA conserved in mice that plays important regulatory roles in interferon-driven innate immunity [20,21,22,23,24] and various cancers [25,26,27,28,29]. This evidence concerns the gene CARINH and colitis.