A transcriptomic analysis, along with the integration of lncRNA expression changes in three ESCC cell lines (KYSE30, KYSE180, and KYSE45) treated with IFNβ, identified nearly 1000 lncRNAs with altered expression levels (499 being upregulated, and 495 downregulated). Here, IFNB1 is linked to esophageal squamous cell carcinoma.