TP53 and Treacher-Collins syndrome: Upregulation of p53 is a well-known mechanism in neurocristopathies, such as CHARGE and Treacher Collins syndrome, as well as in spliceosomopathies like Richieri-Costa-Pereira (OMIM268305), cerebrocostomandibular (OMIM117650) and thrombocytopenia-absent radius (TAR) syndrome (OMIM274000) that also show craniofacial defects (Beauchamp et al., 2020; Tsai et al., 2021; Van Nostrand et al., 2014).