Meanwhile, monocytes act as precursors to macrophage populations in the tumor microenvironment, where they frequently differentiate into alternatively activated, M2-type tumor-associated macrophages (TAMs) under the influence of interleukin-4, interleukin-13, and transforming growth factor-β secreted by both stromal and neoplastic components [15,16]. The gene discussed is IL13; the disease is neoplasm.