IL6 and endothelial dysfunction: Visceral adipose tissue, in particular, functions as a metabolically active endocrine organ that secretes cytokines and adipokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), leptin, and adiponectin, contributing to systemic inflammation, insulin resistance, and endothelial dysfunction [11,12,13,14,15,16].