GLP-1RAs, by increasing insulin, reducing appetite, delaying stomach emptying, and decreasing liver glucose production are a pharmacological class of drugs (the most prescribed drugs include semaglutide, liraglutide, and dulaglutide) that mimic the natural GLP-1 hormone to help manage T2D and obesity by lowering blood sugar and promoting weight loss [22]. The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.