Considering that the density of tumor-infiltrating T lymphocytes is closely associated with disease progression, with a critical role of adaptive immunity within CRC TME [144,145], bioinformatics analyses using CIBERSORT and TIMER on CRC datasets have shown a significant correlation between ANXA1 expression and the infiltration of CD4+ and CD8+ T cells, suggesting a high lymphocyte density in tumors with high ANXA1 expression [128]. Here, CD4 is linked to colorectal carcinoma.