PGP and colorectal carcinoma: Several studies have shown that ANXA1 plays a pivotal role in stimulating the Wnt/β-catenin [192,193] and PI3K/Akt/NF-κB pathways [191], followed by expression of the multidrug resistance protein 1 (MDR1) gene, encoding P-gp, thus contributing to CRC chemoresistance [191,192,193].