Moreover, ANXA1 expression exhibits a weak correlation with M1 macrophages gene markers and a moderate to strong correlation with markers associated with M2 macrophages [128], suggesting that it may play a role in TAMs polarization, favoring the M2 phenotype transition, which is usually associated with a poor prognosis in different cancer types, including CRC [128,141]. Here, ANXA1 is linked to colorectal carcinoma.