In the context of the CRC Consensus Molecular Subtypes (CMS) classification, a strong expression of focal adhesion proteins, such as ANXA1, ANXA6, vimentin, nexilin, filamin, actinin-α1, and caveolin-1, has been associated with CMS4 CRC cells’ resistance to chemotherapy [95]. The gene discussed is ANXA1; the disease is colorectal carcinoma.