EGF and neoplasm: According to their two main subtypes [117,138], M1 macrophages are recognized for their anti-tumor effects by immune responses stimulation [139], whereas M2 macrophages support tumor growth and invasion stimulation by the release of matrix metalloproteinases, angiogenesis promotion by vascular endothelial growth factor A (VEGF-A), and tumor cell survival support by epidermal growth factor (EGF) and fibroblast growth factor-1 (FGF-1) production [117].