For example, a study involving 172 LARC patients found that high levels of ANXA1 were linked to advanced pre-therapeutic T stages (T3 and T4, p = 0.022), advanced pre- and post-therapeutic nodal status (N1/N2, p = 0.004, and p = 0.001, respectively), and a low tumor regression grade following nCRT (p = 0.009) [27]. Here, ANXA1 is linked to neoplasm.