SLC5A5 and neoplasm: One particularly interesting study is the article by Lacoste et al., which convincingly demonstrates the pro-oncogenic role of intracytoplasmic NIS promoting tumor cell migration and metastasis by interacting with the guanine nucleotide exchange factor of Ras Homolog Family Member A Guanosine Triphosphatase (RhoA GTPase) involved in cell adhesion.