PAX5 and precursor B-cell acute lymphoblastic leukemia: This is relevant because many of the observations obtained previously using these mouse models have later been mirrored in pediatric B-ALL patients, as illustrated by the case where the B-cell alterations found in preleukemic Pax5+/− mice [36] were later confirmed in children carrying PAX5 germline variants [61], or by the discovery that B-ALL driver genes are not targeted by AID in mice, subsequently validated in human ALL blasts [49], or by the identification of gut microbiome immaturity in B-ALL-predisposed mice [37], which was also later corroborated in children with B-ALL [62].