The long arm of chromosome 7 harbors several critical genes like Enhancer of Zeste Homolog 2 (EZH2), Mixed-Lineage Leukemia 3 (MLL3), and the cytoplasmic regulators Sterile Alpha Motif Domain–Containing Protein (SAMD9 and SAMD9L), and loss of one copy results in the loss of tumor-suppressor function contributing to leukemogenesis [29]. The gene discussed is EZH2; the disease is neoplasm.