CD274 and non-Hodgkin lymphoma: Although DLBCL exhibits relatively high PD-L1 expression compared with other NHL subtypes, the expressions of PD-1 and PD-L1 are usually heterogeneous (PD-1: 39.5%-68.6%; PD-L1: 25–70% (Xu-Monette, Zhou & Young, 2018)), and PD-L1 structural variations (SVs) can be identified through FISH in only 20–25% of DLBCL patients (more common in non-GCB subtype) (Godfrey et al., 2019).