The possible reason is that when CCBL2 expression is low, there is aberrant activation of the proto-oncogene MYC in BC cells, and upregulation of the MYC pathway drives cancer; altered glutamine metabolism in MYC-driven BC results in glutamine addiction, which leads to decreased survival (Chen & Cui, 2015; Le et al., 2012). The gene discussed is MYC; the disease is cancer.