PRKN and Alzheimer disease: The structural variant landscape of two genes of interest, ABCA7 for AD, which is known to harbor complex structural rearrangements, and PRKN for PD, a long gene with known deletion and duplication alleles, depicts the density of lrGS-discovered variants across both length and frequency spectrum, highlighting the discovery power of performing long-read sequencing to find novel variants near disease genes (Figure 2g).