In AD, one of the strongest examples of an SV tagged by the lead GWAS single-nucleotide variant (SNV) is a 316 bp Alu insertion in the 3’ UTR of TMEM106B (Chemparathy et al. 2024; Vialle et al. 2025; Bellenguez et al. 2022). Here, TMEM106B is linked to Alzheimer disease.