The SAMS/ADRC CSF protein levels of the corresponding SNVs in both genes showed strong colocalization with AD GWAS signals (PP4=0.96 ACE CSF protein levels, Supplementary Figure 7), TMEM106B protein levels (PP4= 0.81 CSF, PP4= 0.91 plasma), as well as GTEx expression (PP4=0.85 brain cortex, and Figure 6c). Here, ACE is linked to Alzheimer disease.