NBEAL1 and ischemic stroke: We found a large intronic deletion in NBEAL1 (chr2:203034349–203039584; 5,235 bp) that is in high LD with SNVs previously reported in AD (Bellenguez et al. 2022, rs139643391 on WDR12, R2 =0.92); small vessel disease (Chung et al. 2019; rs72932727 on ICAIL, R2=0.89); and ischemic stroke and white matter hyperintensities (Traylor et al. 2021; rs7934535 on NBEAL1, R2=0.82) (Figure 6b).