Also present in the credible sets is an Alu element insertion in ACE (chr17:63488532; 291 bp insertion) (Supplementary Figure 6), which has been shown to affect isoform splicing (Wu et al. 2013) and may be a relevant locus for AD (R2=0.4 with rs4277405 reported in AD-GWAS, R2=0.62 with rs4309 in CSF proteomics GWAS) (Cruchaga et al. 2023). This evidence concerns the gene ACE and Alzheimer disease.