SEMA3C and Alzheimer disease: Notably, a subset of proteins: LTBP1, CRIP1, MGP, ACAN, and SEMA3C emerged as significantly associated (p value<0.05) with all three vascular imaging abnormalities and CAA pathology, suggesting their central role as biomarkers of cerebrovascular defects in AD (Figures 5C and 5D and Figure 6).