MAPT and Alzheimer disease: Specifically, a cluster of 13 modules, associated with ECM function (M10, M37), coagulation/immune biology (M73, M57, M72, M52, M49), metabolism (M76, M5, M19, M13), actin cytoskeleton (M25) and protein folding (M42) were significantly elevated in AD (p value<0.05) and positively correlated with pathological accumulation of amyloid and tau in the brain (Figures 2A and 2B).