CRIP1 and infarction: Since CRIP1 protein levels in CSF were positively associated with CAA pathology and all three vascular neuroimaging abnormalities (WMH, microbleeds, and infarcts) in ADNI, we next focused on the genetic variant linked to CSF CRIP1 variation, the protein quantitative trait locus (pQTL) rs35590487 (Figure 7B).