CSF proteomics and high-resolution MRI data from 1,104 participants of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) revealed that ECM proteins such as LTBP1, CRIP1, C1QC, PRSS23, ELN, and CEMIP were associated with vascular imaging abnormalities and neuropathological features of CAA, but not with PET AV45 signal, highlighting their independence from Aβ plaques. This evidence concerns the gene CRIP1 and Alzheimer disease.