Notably, a subset of proteins: LTBP1, CRIP1, MGP, ACAN, and SEMA3C emerged as significantly associated (p value<0.05) with all three vascular imaging abnormalities and CAA pathology, suggesting their central role as biomarkers of cerebrovascular defects in AD (Figures 5C and 5D and Figure 6). This evidence concerns the gene ACAN and Alzheimer disease.