For example, our quadruplet for prostate cancer links genetic risk to the ACPP gene within prostate epithelial cells—the very cells where prostatic acid phosphatase (ACPP) is known to be synthesized.51,52 Similarly, our link between KCNQ1OT1 and genetic susceptibility to renal cancer in bulk kidney tumor tissue is supported by the gene’s known high expression in KIRC tumors.53 Beyond reinforcing known interactions, these quadruplets propose novel testable mechanisms, each defining a full regulatory path from variant to gene, context, and ultimately, to cancer. Here, KCNQ1OT1 is linked to kidney neoplasm.