This analysis yielded high-confidence regulatory mechanisms for particular SNPs within tissue-of-origin contexts for overall and ER+ breast cancer (e.g., rs68056147-LINC-PINT-mammary luminal epithelial cells), prostate cancer (e.g., rs3916132-ACPP-VCaP), colorectal cancer (only one quadruplet found: rs35943851-METRNL-COAD), and renal cancer (e.g., rs11023840-KCNQ1OT1-KIRC). This evidence concerns the gene METRNL and breast cancer.