CDKN1A and cancer: For example, the RHOD locus (11q13.2) is implicated in both ER+ breast cancer (mammary luminal epithelial cells) and prostate cancer (VCaP and PRAD) specifically through variant rs114895445, and the CDKN1A locus (6p21.2) is linked to both prostate (VCaP) and renal cancer (KIRC) through variant rs762624 (illustrated as an example in Figure 3), highlighting cancer-shared genetic pathways that may be activated through distinct biological contexts.