ESR1 and colorectal cancer: CT-FM substantially refined the initial S-LDSC results (Table 2, Figure 2), identifying four contexts achieved high confidence (PIPs ≥ 0.5): mammary luminal epithelial cells for both overall and ER+ breast cancer (PIP = 0.62–0.75), VCaP prostate adenocarcinoma epithelial cell line for prostate cancer (PIP = 1.00), colon adenocarcinoma (COAD) bulk tissue for colorectal cancer (PIP = 1.00), and kidney renal clear cell carcinoma (KIRC) bulk tissue for renal cancer (PIP = 0.73).