HP and Alzheimer disease: Following GWAS and xQTL investigation, we focused on 3 variants: rs79940707–the female AD index variant–showing strong LD (in EUR) with the known HP1F tag variant (R2=0.75) and some LD with HP1 (R2=0.27), rs77303550–the top CSF HP pQTL–showing strong LD with the known tag variant for HP1S (R2=0.97) and some LD with HP1 (R2=0.41), and rs34042070–the top brain pQTL and multi-tissue eQTL largely LD-independent of HP structural variants (Fig.6A–B, Fig.S29, Table-S35).