These comprised 28 novel genes at novel AD loci, 6 novel genes at known loci, and 3 known AD genes (Table 2), with 4 loci overlapping the 20 sex-biased GWAS loci (Fig.1; INPP5D, TSPAN14, KRTCAP2/GBA1, PMBFBP1/HP). The gene discussed is HP; the disease is Alzheimer disease.