Seeking to understand how rs79940707/HP1F may affect AD risk, and in light of the established HP-APOE link39, we conducted sex-by-APOE stratified analyses which showed the association of rs79940707/HP1F with AD risk was more pronounced in female APOE ε33 and ε23 carriers (ORAPOE*33=1.12, PAPOE*33=0.005; ORAPOE*23=1.28, PAPOE*23=0.019; Fig.6C, Table-S37), corroborating an interaction with APOE biology. This evidence concerns the gene APOE and Alzheimer disease.