To elucidate the relationship between the female-specific genetic signal, HP structural variants, and AD, we leveraged novel long-read sequencing (LRS) data from the Stanford ADRC/SAMS cohorts to assess LD and perform HP1 genotype imputation in Stage-1–2 GWAS and CSF/plasma pQTL data (Fig.6A; Figs.S27–28, Table-S34; cf. Methods)53. This evidence concerns the gene HP and Alzheimer disease.