Of the 20 loci, 11 were signals reported in previous AD GWAS, 4 were novel independent signals at known loci (Table-S5), and 5 were novel loci, including female-biased ALPL, SHC3, PMFBP1 and male-biased KRTCAP2, WDFY1-AP1S3 (locus names reflect most proximal genes; locus plots with all mapped signals Fig.S4; variant forest plots Fig.S5). The gene discussed is SHC3; the disease is Alzheimer disease.