Across novel loci, only ALPL was marked by a rare missense variant, rs121918007 (ORFemales=0.68, PFemales=4.0e-9, ORMales=0.90, PMales=0.067), with a high predicted deleteriousness score (Table-S6) and detection enabled by inclusion of FinnGen given elevated frequencies in Finnish versus non-Finnish Europeans (gnomAD AF 1.70% versus 0.14%). This evidence concerns the gene ALPL and atrial fibrillation.