HTRA1 and age-related macular degeneration: Since the original 2006 discovery report for ARMS2-HTRA1 region,27 attempts to directly link ARMS2 or HTRA1 expression with AMD have yielded inconsistent results, often due to limited sample sizes.19 By analyzing 43 AMD and 44 control retinas, our study represents the largest cohort to date demonstrating lncRNA dysregulation at this locus.