For instance, the LIL peptide, derived from a two-amino-acid open reading frame, promotes cell growth.28 Notably, the AMD-associated SNP rs61871745 (G/A; A as the risk allele) is located within predicted coding regions of HTRA1-AS1 and ENST00000647969.1. The gene discussed is HTRA1; the disease is age-related macular degeneration.