A recent preprint reported the same lncRNA (BX842242.1/ENSG00000285955) associated with reticular pseudodrusen (RPD), with elevated expression correlating with reduced HTRA1 levels.26 In contrast, our data demonstrate that HTRA1-AS1 is significantly downregulated in AMD retinas, whereas HTRA1 mRNA expression was unchanged between cases and controls. The gene discussed is HTRA1; the disease is age-related macular degeneration.