The interaction between BMD PRS and treatment on ASDAS-CRP remained significant after conditioning on the PRS of ankylosing spondylitis (estimated PRSxT coefficient = 0.477, P = 0.0007) and the PRS of CRP (estimated PRSxT coefficient = 0.903, P = 5.2e-5). The gene discussed is CRP; the disease is ankylosing spondylitis.