BARD1 and cancer: Notably, the odds ratios for LoF missense variants (both all LoF missense and those only in the structured domains) were not significantly different from those of protein truncating variants (Supplementary Table 1) (p = 0.97 and p = 0.99 respectively, Z-test), suggesting that LoF missense and truncating BARD1 variants confer similar cancer risk.