If those categories were removed, then 12 additional proteins would show specific subtype associations including AKI (ANXA2, FAM213A, FGF5, GPX1, MST1), Cystic (A4GALT), nephrotic (AGER, CFHR1), Type 2 DKD (APOE, GSTA1, INHBC, PCK1). This evidence concerns the gene ANXA2 and acute kidney injury.