Some of these represent known biomarkers of kidney disease (IDI2 as a robust indicator of kidney function in multiple prior studies16,17, EFNA3 gene variants have been determinants of kidney function and albuminuria6,18, and BTN3A2 is an immune-regulatory protein enriched in immune cells and genetically linked to CKD, including IgA nephropathy)2. The gene discussed is EFNA3; the disease is chronic kidney disease.