Beyond the synaptic modules, association strengths diverged: stress-response and proteostasis modules, including MAPK/metabolism (M7), proteasome (M30), and protein folding (M14), were stronger for ADAS-Cog11, consistent with its sensitivity to early cognitive decline, whereas modules reflecting structural disconnection and circuit-level remodeling, including axonogenesis (M19), were stronger for CDR-SB, aligning with its emphasis on later functional impairment (Fig. 5c). Here, AGPS is linked to Mental deterioration.