As expected, the most predictive proteins spanned a wide swath of AD biology, capturing synaptic (NPTX2, PNOC, YWHAZ, YWHAE, PPP3CA), presynaptic (UCHL1), ECM (ADAMTS1, ADAMTSL3), neuronal-signaling (BMP7), neuroinflammatory (RELT, CTSS, LILRB4), and metabolic (FABP3, GAA, SPINT1, GNPTG, FAM3B) processes, highlighting that progression is foreshadowed by coordinated disruption across multiple molecular systems (Fig. 4d). The gene discussed is NPTX2; the disease is Alzheimer disease.