It can also downregulate the expression of amyloid precursor protein (APP) cleaving enzymes to inhibit the accumulation of Aβ and the abnormal phosphorylation of Tau protein, improve the neurofibrillary tangles (NFTs) caused by abnormal Tau phosphorylation, and drive the non-amyloidogenic pathway to prevent Alzheimer’s disease (AD) (Shi et al., 2020; Li and Qian, 2016; Zhang et al., 2016). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.