In addition, it can significantly reduce the production of pro-inflammatory factors such as IL-6, IL-1, IL-8, CXCL10 and TNF-α at the mRNA level, downregulate the expression of inflammatory cytokines induced by virus in vitro, regulate the activity of NF-κB signaling pathway, and ultimately alleviate the symptoms of COVID-19 and cytokine storms, inhibit sarS-COV-2 virus infection (Ma et al., 2020). This evidence concerns the gene TNF and COVID-19.