The protein genes IL2, ALB, FOS, PTGS2, and TNF-α act on the PI3K/Akt signaling pathway to promote the production of eNOS and VEGF, exerting multiple functions such as antiviral, immune regulation, and organ protection, thereby producing dual effects of antiviral and vascular protection, and the further conclusion is that their main ingredients include Licorice glycoside E and xambioona may be the key compounds in the treatment of COVID-19 (Li X. et al., 2021). This evidence concerns the gene AKT1 and COVID-19.