For instance, mitophagy can act as a tumor-suppressive mechanism (as suggested by the association between its inhibitor LRPPRC and poor prognosis), yet it also serves as a survival mechanism for cancer cells under stress(Balvan et al., 2015; Zou et al., 2014; Schaaf et al., 2024; Morshed et al., 2025). This evidence concerns the gene LRPPRC and cancer.