Accumulating evidence indicates that ST8SIA6-AS1 is aberrantly overexpressed in various solid tumors, exhibiting strong tumor-promoting effects in hepatocellular carcinoma (Zhang X. et al., 2020; Xue et al., 2023; Feng et al., 2023; Fei et al., 2020), cholangiocarcinoma (He et al., 2021), breast cancer (Fang et al., 2020; Luo et al., 2020; Chen et al., 2021; Wang et al., 2024), colorectal cancer (Wang et al., 2023), and lung cancer (Luo et al., 2020; Wang et al., 2023; Cao et al., 2020). Here, ST8SIA6 is linked to hepatocellular carcinoma.