For instance, upregulation of ATG5 depresses the sensitivity of prostate and lung cancer cells to chemotherapy by inducing autophagy (Cristofani et al., 2018; Wang et al., 2022), whereas silencing of ATG5 suppresses autophagy and increases the sensitivity to imatinib mesylate (Tong et al., 2012). The gene discussed is ATG5; the disease is lung cancer.