Wang et al. (2016) explored the role of chromatin remodeling in autoimmune diseases, including systemic lupus erythematosus, systemic sclerosis, and multiple sclerosis. Liu et al. (2024) demonstrated that chromatin remodeling inhibits inflammation in animal models of experimental autoimmune encephalomyelitis and colitis. At present, we are still unable to confirm whether there is a relationship between SRCAP and AE. The gene discussed is SRCAP; the disease is experimental autoimmune encephalomyelitis.