PLOD1 and hypogonadotropic hypogonadism: Instead, it reduces the response of luteinizing hormone to gonadotropin-releasing hormone by decreasing the exocytosis of LH stimulated by GnRH leading to neurodegeneration and impaired pituitary gonadotropin release, resulting in hypogonadotropic hypogonadism (Topaloglu et al., 2014).