While a large portion of the scientific literature associates this genus with beneficial traits such as improved insulin sensitivity in metabolically healthy obese individuals (7–9), reduced inflammation, enhance anti-inflammatory molecules, mucin production and tight junctions restoration (10, 11), other studies linked it to with small intestine bacterial overgrowth (12), depressive symptoms (13), inflammatory bowel disease (14), liver tumorigenesis (15) and interstitial cystitis (16). The gene discussed is MUC5AC; the disease is interstitial cystitis.