Adjusted for gender, age, smoking status, duration of diabetes, BMI, SBP and DBP, LDL-C, eGFR, Charlson's comorbidity index, and use of anti-hypertensive drugs, oral antidiabetic drugs, including metformin, sulphonylureas and other oral diabetes drugs, insulin, and lipid-lowering agents. This evidence concerns the gene INS and diabetes mellitus.