Among these, several are involved in key cellular processes: BCL2L11 and TP53 are associated with apoptosis; MAP2K4, MAPK14, and SP1 are linked to inflammatory signaling and cellular stress, while IFNG and its receptor (IFNGR) participate in inflammatory cytokine signaling implicated in beta-cell apoptosis and insulin resistance. This evidence concerns the gene SP1 and Insulin resistance.