Building upon those findings, the present study aimed to investigate whether treatment with sitagliptin or bedtime NPH insulin was associated with changes in circulating miRNA expression profiles, related to T2D and/or insulin resistance: miR-24-3p, miR30c-5p (4), miR-193b-3p (12), miR-335-5p (13), miR-199a-3p, miR-532-5p, let-7d-5p (14), miR-27a-3p (15), miR-660-5p (16), miR-92a-3p and miR-320-3p (6). This evidence concerns the gene INS and type 2 diabetes mellitus.